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Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment.

J Cosmet Dermatol. 2020 Apr;19(4):855-862

Authors: Ebrahim HM, Albalate W

Abstract
BACKGROUND: Combination therapies have reported to augment the repigmentation in vitiligo. Microneedling (Mn) facilitates drug delivery across the skin barrier.
OBJECTIVE: To evaluate and compare the efficacy and safety of Mn combined with tacrolimus vs Mn alone or tacrolimus 0.1% ointment for treatment of localized and stable vitiligo.
PATIENTS AND METHOD: Ninety patients with vitiligo were randomized into three groups: group I received microneedling with tacrolimus, group II microneedling only both at 2 weeks interval for twelve sessions, and group III applied tacrolimus ointment 0.1% twice daily for 6 months. Skin biopsies were taken at baseline and after treatment.
RESULTS: The overall improvement (76.6%) was significantly higher in the combined group compared with other groups. Repigmentation was excellent in 66.6 of group I vs 33.3% in the other two groups (P .03). A highly significant improvement of the extremities was observed in the combined group than in the other groups (P < .001). A fewer number of sessions have reported in the combined group (I) than in the microneedling group (II; P < .001). Immunohistochemical results showed a significantly higher expression of HMB-45 in group I than in other two groups (P .04). Side effects were mild and tolerable in all groups.
CONCLUSION: The combination group has shown promising results over the other two groups.

PMID: 32030880 [PubMed – indexed for MEDLINE]