J Cosmet Dermatol. 2026 Apr;25(4):e70881. doi: 10.1111/jocd.70881.

ABSTRACT

BACKGROUND: Microneedling combined with exosome therapy has growing clinical relevance in dermatology. This systematic review will critically evaluate current evidence on the combined use of microneedling and exosomes in a number of dermatological diseases.

METHOD: A systematic literature search was conducted using terms related to exosomes and microneedling using 3 databases in accordance with the Preferred Reporting Items for Systematic Reviews and synthesis (PRISMA) without meta-analyses (SWiM) guidelines. Studies were appraised using the JBI (Joanna Briggs Institute) Critical Appraisal tool.

RESULTS: Two hundred and fifty-six unique references were identified, and after screening, 10 studies were eligible for quality appraisal, after which 8 studies were selected for inclusion in the final narrative synthesis. Sample size of the studies ranged from 3 from 60 participants. The efficacy and side effect profiles of exosomes and microneedling were evaluated in the following dermatological conditions: androgenetic alopecia, skin aging, hyperpigmentation, active scarring, and enlarged pores.

CONCLUSION: Microneedling and exosomes hold great promise in a range of dermatological conditions. This study highlights that more evidence is required before we can ascertain the safety profile and efficacy profile of microneedling and exosomes. Further investigation with longer follow-up periods and larger sample sizes is necessary to determine the long-term safety profile and effectiveness of this treatment.

PMID:42027180 | DOI:10.1111/jocd.70881