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Clinical Efficacy of Topical Tranexamic Acid With Microneedling in Melasma.

Dermatol Surg. 2020 11;46(11):e96-e101

Authors: Kaur A, Bhalla M, Pal Thami G, Sandhu J

Abstract
BACKGROUND: Melasma is a common, recurrent, and refractory cause of facial pigmentation resulting in cosmetic disfigurement. Tranexamic acid (TA) has been used systemically and locally for clearance of pigmentation.
OBJECTIVE: To assess the clinical efficacy of topical TA (10%) with microneedling in melasma.
METHODS: A split face, prospective, randomized, open-label study with a sample size of 40. Left or right side of the face was chosen randomly and microneedling was done on both the sides, followed by 10% TA solution application on one side of the face (test side) and distilled water on the other side of face (control). The procedure was done at 2 weekly intervals (0, 2, 4, and 6 weeks). Clinical images were taken at each visit including modified Melasma Area and Severity Index (mMASI) scoring of each half of the face to assess the clinical response along with patient satisfaction scores and side effects.
RESULTS: On the test side, there was 65.92% improvement in the mean mMASI score compared with 20.75% on the control side of the face at the end of 8 weeks.
CONCLUSION: Tranexamic acid may be a promising therapeutic agent in melasma and the topical solution along with microneedling seems to be efficacious.

PMID: 32769524 [PubMed – indexed for MEDLINE]